Preliminary evaluation of Sida rhombifolia L. toxicity, genotoxicity and antimicrobial activity
The current tendency to consume more natural products and difficult availability of and access to medicines in many regions has led the world’s population to seek other alternatives for relieving their ailments. A return to ancestral medicine has been one of the most widely used alternatives in Colombia, provoking increased phytotherapeutic consumption. The Sida rhombifolia L. plant was selected for this investigation; Daphnia magna, Hydra attenuata and Artemia salina extracts and fractions were used as test organisms for toxicity evaluation. Biological activity was evaluated by sensitivity to antimicrobial test and genotoxicity by Comet assay. Acute toxicity with test organisms showed that aqueous extracts were practically non-toxic (CL50 >1,000 ppm), suggesting that they can be safely used in infusions. Ethanol extracts and ethyl acetate and chloroform fractions revealed antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa; this could have been due to secondary metabolites (terpenoids, flavonoids) present in these species. Ethanol extracts presented important genotoxicity (CL50 35 ppm); it is worth pointing out that the leaves’ aqueous extracts displayed low genotoxicity (CL50 900 ppm) which is important when taking into account that they are the part of the plant traditionally used by indigenous communities located in the Sierra Nevada de Santa Marta in Colombia.
| Main Authors: | , |
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| Format: | Digital revista |
| Language: | spa |
| Published: |
Universidad Nacional de Colombia - Sede Bogotá - Instituto de Biotecnología
2007
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| Online Access: | https://revistas.unal.edu.co/index.php/biotecnologia/article/view/702 |
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