Kawasaki-Like Disease, a New Phenotype in Sars-CoV-2?

Abstract The coronavirus disease (COVID-19), that assumed pandemic proportions in March 2020, mainly affects the respiratory tract, causing severe interstitial pneumonia in adults. Worldwide data indicate that COVID-19 tends to be more benign in children, which is evidenced by a high incidence of asymptomatic or mild upper airways’ infection cases in this population. However, recent studies have been associating Kawasaki-like symptoms as a nonclassical presentation of coronavirus disease in pediatrics. It is suggested that the intense cytokine cascade, promoted by the SARS-CoV-2 infection, can trigger a multisystem inflammatory response as an atypical Kawasaki form in genetically predisposed individuals. In this context, patients may develop more severe clinical features with a greater predisposition to myocardial involvement, Macrophage Activation Syndrome, and Kawasaki Disease Shock Syndrome. Despite critical conditions, patients usually respond to conventional treatment of Kawasaki Disease with intravenous immunoglobulin. This article intends to provide an approach to the association between Kawasaki-Like Syndrome and COVID-19.

Bibliographic Details

Main Authors:	Chara,Beatriz Sordi, Rickli,Júlia Machado, Silva,Caroline Figueiredo da, Pomaleski,Gabriela, Ronsoni,Rafael de March, Gonçalves,Marcus Vinícius Magno
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Cardiologia 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021000500566
Tags:	Add Tag No Tags, Be the first to tag this record!