Development of a mouse computational model for MCNPx based on Digimouse (r) images and dosimetric assays

ABSTRACT The aim of this study was to create and test a new mice 3D-voxel phantom named DM_BRA for mice and human first-estimation radiopharmaceutical dosimetry. Previously, the article reviews the state-of-art in animal model development. Images from Digimouse CT database were used in the segmentation and on the generation of the voxelized phantom. Simulations for validation of the DM_BRA model was performed at 0.015, 0.1, 0.5, 1 and 4 MeV photons with heart-source. Specific Absorbed Fractions (SAF) data were compared with literature data. The organ masses of DM_BRA correlated well with existing models based on the same dataset; however, few small organ masses hold significant variations. The SAF data in most simulated cases were statistically equal to a significant level of 0.01 to the reference data.

Bibliographic Details

Main Authors:	Mendes,Bruno Melo, Almeida,Iassudara Garcia de, Trindade,Bruno Machado, Fonseca,Telma Cristina Ferreira, Campos,Tarcísio Passos Ribeiro de
Format:	Digital revista
Language:	English
Published:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2017
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100622
Tags:	Add Tag No Tags, Be the first to tag this record!