Inflammatory response caused by larvae and adults of Gnathostoma (Nematoda: Gnathostomatidae) in vertebrates of Mexico, including humans
The aim of this study was to describe and compare the inflammatory reaction caused by Gnathostoma spp., in various tissues of wild vertebrates and humans in Mexico. Parasitized tissues were collected from 10 species of vertebrates from 8 states. Samples were fixed in 10% formalin, pH 7.2 and processed with standard histological techniques. The lesions were classified into 4 categories. The advanced third stage larvae in fish, amphibians, and reptiles were associated with inflammatory reaction categories I and II (no injury, discrete or minimum); birds presented lesions classified in categories II, III, and IV (injuries minimal to discrete, moderate to severe; granulomatous); 1 human sample had lesions classified in categories III and IV (injuries moderate to severe; granulomatous). Adult parasites in mammals generated responses in categories III and IV. Inflammatory reactions observed in the different studied vertebrates suggest a complex host response to the presence of the parasite, causing variable tissue changes. The tissue reactions provide basic knowledge on the general principles of the pathogenesis and pathology of gnathostomiasis.
| Main Authors: | , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Instituto de Biología
2014
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-34532014000300008 |
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