Synthesis, Characterization and Cytotoxic Activity of Tioconazole Coordination Compounds with Nickel(II), Palladium(II) and Platinum(II)
Abstract. Coordination compounds of nickel(II), palladium(II) and platinum(II) with tioconazole (tcnz) were synthesized and characterized by infrared, UV-Vis-NIR, elemental analysis, molar conductivity, magnetic susceptibility, mass spectrometry, NMR spectroscopy and X-ray diffraction. Tioconazole presented a monodentate coordination mode, through the nitrogen atom of the imidazolic ring. The nickel(II) compounds stabilized octahedral geometries. For the [Ni(tcnz)2(NO3)2].H2O compound, the nitrate anion present a bidentate coordination mode, while for the dinuclear [Ni(tcnz)2(OAc)2]2 .3H2O compound, the acetate groups behave as bridging ligands. When different molar ratios of the corresponding nickel(II) halides were used on the reaction synthesis, three tcnz ligands in the [Ni(tcnz)3Br2(H2O)], or six in [Ni(tcnz)6]Cl2 and [Ni(tcnz)6]Br2, are coordinated to the nickel(II) atom. The palladium(II) and platinum(II) compounds, [Pd(tcnz)2Cl2], [Pt(tcnz)2Cl2].2H2O and [Pd(tcnz)2(OAc)2], presented a square planar geometry. The [Ni(tcnz)6]X2 (X- = Cl, Br) compounds stabilized 3D supramolecular arrangements through hydrogen bonding and (∙∙∙( stacking interactions, between benzene rings of neighboring molecules. The in vitro cytotoxic activity of the synthesized compounds was studied in four different human carcinoma cell lines: HCT-15 (colon), HeLa (cervix-uterine), MCF-7 (breast) and PC-3 (prostate).
| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2018
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2018000400225 |
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