Stereochemical Investigation of a Novel Biological Active Substance from the Secondary Metabolites of Marine Fungus Penicillium chrysogenum SYP-F-2720
The chemical structure and absolute configuration of a novel benzoic acid (1) which is the secondary metabolites from the marine fungus Penicillium chrysogenum SYP-F-2720, has been determined by experimental spectroscopic data and quantum chemical calculations of its electronic circular dichroism (ECD). The configurational assignments were further confirmed by the highly consistent spectra between natural compound and synthetic compound which from raw material with a definite configuration. Furthermore, The target compound exhibited more significant anti-inflammatory and analgesic activities than aspirin when administered at 100 mg/kg, however, it behaved no ulcerogenic effect.
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| Main Authors: | , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2015
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2015000100010 |
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