Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis
Intraperitoneal free cancer cells in gastric adenocarcinoma are associated with a poor outcome. However, the true prognostic value of intraperitoneal free cancer cells is still unclear, leading to a lack of consensus in the management of gastric cancer. The aim of the present study is to perform a systematic review and meta-analysis to analyze intraperitoneal free cancer cells-positive patients with regard to tumor oncologic stage, recurrence, grade of cellular differentiation, and survival rates and to analyze the clinical significance of intraperitoneal free cancer cells with regard to prognosis. Databases were searched up to January 2016 for prognostic factors associated with intraperitoneal free cancer cells, including oncologic stage, depth of neoplasm invasion, lymph nodal spread, differentiation grade of the tumor, and recurrence and survival rates. A total of 100 studies were identified. Meta-analysis revealed a clear association between intraperitoneal free cancer cells and a poor prognosis. intraperitoneal free cancer cells -positive patients had higher rates of nodal spread (risk difference: 0.29; p<0.01), serosal invasion (risk difference: 0.43; p<0.01), recurrence (after 60 months of follow-up, risk difference: 0.44; p<0.01), and mortality (after 60 months of follow-up, risk difference: 0.34; p<0.01). Intraperitoneal free cancer cells are associated with a poor outcome in gastric cancer. This surrogate biomarker should be used to guide therapy both prior to and after surgery.
Main Authors: | , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Faculdade de Medicina / USP
2016
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200733 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1807-59322016001200733 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1807-593220160012007332017-01-03Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysisTustumi,FranciscoBernardo,Wanderley MarquesDias,Andre RonconRamos,Marcus Fernando Kodama PertilleCecconello,IvanZilberstein,BrunoRibeiro-Júnior,Ulysses Gastric Carcinoma Peritoneal Washing Peritoneal Lavage Cytology Carcinoembryonic Antigen RT-PCR Intraperitoneal free cancer cells in gastric adenocarcinoma are associated with a poor outcome. However, the true prognostic value of intraperitoneal free cancer cells is still unclear, leading to a lack of consensus in the management of gastric cancer. The aim of the present study is to perform a systematic review and meta-analysis to analyze intraperitoneal free cancer cells-positive patients with regard to tumor oncologic stage, recurrence, grade of cellular differentiation, and survival rates and to analyze the clinical significance of intraperitoneal free cancer cells with regard to prognosis. Databases were searched up to January 2016 for prognostic factors associated with intraperitoneal free cancer cells, including oncologic stage, depth of neoplasm invasion, lymph nodal spread, differentiation grade of the tumor, and recurrence and survival rates. A total of 100 studies were identified. Meta-analysis revealed a clear association between intraperitoneal free cancer cells and a poor prognosis. intraperitoneal free cancer cells -positive patients had higher rates of nodal spread (risk difference: 0.29; p<0.01), serosal invasion (risk difference: 0.43; p<0.01), recurrence (after 60 months of follow-up, risk difference: 0.44; p<0.01), and mortality (after 60 months of follow-up, risk difference: 0.34; p<0.01). Intraperitoneal free cancer cells are associated with a poor outcome in gastric cancer. This surrogate biomarker should be used to guide therapy both prior to and after surgery.info:eu-repo/semantics/openAccessFaculdade de Medicina / USPClinics v.71 n.12 20162016-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200733en10.6061/clinics/2016(12)10 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Tustumi,Francisco Bernardo,Wanderley Marques Dias,Andre Roncon Ramos,Marcus Fernando Kodama Pertille Cecconello,Ivan Zilberstein,Bruno Ribeiro-Júnior,Ulysses |
spellingShingle |
Tustumi,Francisco Bernardo,Wanderley Marques Dias,Andre Roncon Ramos,Marcus Fernando Kodama Pertille Cecconello,Ivan Zilberstein,Bruno Ribeiro-Júnior,Ulysses Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
author_facet |
Tustumi,Francisco Bernardo,Wanderley Marques Dias,Andre Roncon Ramos,Marcus Fernando Kodama Pertille Cecconello,Ivan Zilberstein,Bruno Ribeiro-Júnior,Ulysses |
author_sort |
Tustumi,Francisco |
title |
Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
title_short |
Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
title_full |
Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
title_fullStr |
Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
title_full_unstemmed |
Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
title_sort |
detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis |
description |
Intraperitoneal free cancer cells in gastric adenocarcinoma are associated with a poor outcome. However, the true prognostic value of intraperitoneal free cancer cells is still unclear, leading to a lack of consensus in the management of gastric cancer. The aim of the present study is to perform a systematic review and meta-analysis to analyze intraperitoneal free cancer cells-positive patients with regard to tumor oncologic stage, recurrence, grade of cellular differentiation, and survival rates and to analyze the clinical significance of intraperitoneal free cancer cells with regard to prognosis. Databases were searched up to January 2016 for prognostic factors associated with intraperitoneal free cancer cells, including oncologic stage, depth of neoplasm invasion, lymph nodal spread, differentiation grade of the tumor, and recurrence and survival rates. A total of 100 studies were identified. Meta-analysis revealed a clear association between intraperitoneal free cancer cells and a poor prognosis. intraperitoneal free cancer cells -positive patients had higher rates of nodal spread (risk difference: 0.29; p<0.01), serosal invasion (risk difference: 0.43; p<0.01), recurrence (after 60 months of follow-up, risk difference: 0.44; p<0.01), and mortality (after 60 months of follow-up, risk difference: 0.34; p<0.01). Intraperitoneal free cancer cells are associated with a poor outcome in gastric cancer. This surrogate biomarker should be used to guide therapy both prior to and after surgery. |
publisher |
Faculdade de Medicina / USP |
publishDate |
2016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200733 |
work_keys_str_mv |
AT tustumifrancisco detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis AT bernardowanderleymarques detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis AT diasandreroncon detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis AT ramosmarcusfernandokodamapertille detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis AT cecconelloivan detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis AT zilbersteinbruno detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis AT ribeirojuniorulysses detectionvalueoffreecancercellsinperitonealwashingingastriccancerasystematicreviewandmetaanalysis |
_version_ |
1756432285431758848 |