Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series
ABSTRACT This brief communication demonstrates the correlation of persistent respiratory symptoms with functional, tomographic, and transbronchial pulmonary biopsy findings in patients with COVID-19 who had a long follow-up period. We report a series of six COVID-19 patients with pulmonary involvement who presented with persistent dyspnea within 4-15 months of discharge. We performed transbronchial biopsies, and the histopathological pattern consistently demonstrated peribronchial remodeling with interstitial pulmonary fibrosis. Therefore, lung biopsy may be useful in the approach of patients with long COVID-19, although the type of procedure, its precise indication, and the moment to perform it are yet to be clarified. (Brazilian Registry of Clinical Trials-ReBEC; identifier: RBR-8j9kqy [http://www.ensaiosclinicos.gov.br])
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Sociedade Brasileira de Pneumologia e Tisiologia
2022
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oai:scielo:S1806-371320220003003002022-04-25Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case seriesBaldi,Bruno GuedesFabro,Alexandre TodorovicFranco,Andreia CraveiroMachado,Marília Helena CPrudente,Robson AparecidoFranco,Estefânia ThoméMarrone,Sergio RibeiroVale,Simone Alves doCezare,Talita JaconMoraes,Marcelo Padovani de ToledoFerreira,Eloara Vieira MachadoAlbuquerque,André Luis PereiraSawamura,Marcio Valente YamadaTanni,Suzana Erico COVID-19 COVID-19/pathology Pulmonary fibrosis Respiratory function tests Biopsy ABSTRACT This brief communication demonstrates the correlation of persistent respiratory symptoms with functional, tomographic, and transbronchial pulmonary biopsy findings in patients with COVID-19 who had a long follow-up period. We report a series of six COVID-19 patients with pulmonary involvement who presented with persistent dyspnea within 4-15 months of discharge. We performed transbronchial biopsies, and the histopathological pattern consistently demonstrated peribronchial remodeling with interstitial pulmonary fibrosis. Therefore, lung biopsy may be useful in the approach of patients with long COVID-19, although the type of procedure, its precise indication, and the moment to perform it are yet to be clarified. (Brazilian Registry of Clinical Trials-ReBEC; identifier: RBR-8j9kqy [http://www.ensaiosclinicos.gov.br])info:eu-repo/semantics/openAccessSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia v.48 n.3 20222022-01-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000300300en10.36416/1806-3756/e20210438 |
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Baldi,Bruno Guedes Fabro,Alexandre Todorovic Franco,Andreia Craveiro Machado,Marília Helena C Prudente,Robson Aparecido Franco,Estefânia Thomé Marrone,Sergio Ribeiro Vale,Simone Alves do Cezare,Talita Jacon Moraes,Marcelo Padovani de Toledo Ferreira,Eloara Vieira Machado Albuquerque,André Luis Pereira Sawamura,Marcio Valente Yamada Tanni,Suzana Erico |
spellingShingle |
Baldi,Bruno Guedes Fabro,Alexandre Todorovic Franco,Andreia Craveiro Machado,Marília Helena C Prudente,Robson Aparecido Franco,Estefânia Thomé Marrone,Sergio Ribeiro Vale,Simone Alves do Cezare,Talita Jacon Moraes,Marcelo Padovani de Toledo Ferreira,Eloara Vieira Machado Albuquerque,André Luis Pereira Sawamura,Marcio Valente Yamada Tanni,Suzana Erico Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series |
author_facet |
Baldi,Bruno Guedes Fabro,Alexandre Todorovic Franco,Andreia Craveiro Machado,Marília Helena C Prudente,Robson Aparecido Franco,Estefânia Thomé Marrone,Sergio Ribeiro Vale,Simone Alves do Cezare,Talita Jacon Moraes,Marcelo Padovani de Toledo Ferreira,Eloara Vieira Machado Albuquerque,André Luis Pereira Sawamura,Marcio Valente Yamada Tanni,Suzana Erico |
author_sort |
Baldi,Bruno Guedes |
title |
Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series |
title_short |
Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series |
title_full |
Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series |
title_fullStr |
Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series |
title_full_unstemmed |
Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series |
title_sort |
clinical, radiological, and transbronchial biopsy findings in patients with long covid-19: a case series |
description |
ABSTRACT This brief communication demonstrates the correlation of persistent respiratory symptoms with functional, tomographic, and transbronchial pulmonary biopsy findings in patients with COVID-19 who had a long follow-up period. We report a series of six COVID-19 patients with pulmonary involvement who presented with persistent dyspnea within 4-15 months of discharge. We performed transbronchial biopsies, and the histopathological pattern consistently demonstrated peribronchial remodeling with interstitial pulmonary fibrosis. Therefore, lung biopsy may be useful in the approach of patients with long COVID-19, although the type of procedure, its precise indication, and the moment to perform it are yet to be clarified. (Brazilian Registry of Clinical Trials-ReBEC; identifier: RBR-8j9kqy [http://www.ensaiosclinicos.gov.br]) |
publisher |
Sociedade Brasileira de Pneumologia e Tisiologia |
publishDate |
2022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000300300 |
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