Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus

ABSTRACTPurpose:The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials and Methods:Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients.

Bibliographic Details

Main Authors:	Koifman,Leandro, Ornellas,Paulo, Ornellas,Antonio Augusto, Pereira,Denise de Abreu, Zingali,Benedeta Russolina, Cavalcanti,Silvia Maria Baeta, Afonso,Larissa Alves, Sandim,Vanessa, Alves,Gilda
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Urologia 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000400642
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