Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

OBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. RESULTS: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. CONCLUSION: In patients with refractory TLE-MTS, the presence of depression predicts an unfavorable outcome.

Bibliographic Details

Main Authors:	Araújo Filho,Gerardo Maria de, Gomes,Francinaldo Lobato, Mazetto,Lenon, Marinho,Murilo Martinez, Tavares,Igor Melo, Caboclo,Luís Otávio Sales Ferreira, Yacubian,Elza Márcia Targas, Centeno,Ricardo Silva
Format:	Digital revista
Language:	English
Published:	Liga Brasileira de Epilepsia (LBE) 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000100006
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