Molecular analysis of translocations associated with Ewing sarcoma: case report

ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation.

Bibliographic Details

Main Authors:	Soares,Leonardo R., Bayeh,Hugo A., Albuquerque,Izabela Cristina, Moreira,Marise A. R., Coutinho,Miguel A. C., Rodrigues,Debora F., Queiroz,Paula O. C., Freitas-Junior,Ruffo
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Patologia Clínica 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000200218
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