Aberrant immunophenotypes in acute lymphoblastic leukemia
Abstract Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic neoplasia worldwide. To classify leukemia, we analyzed the immunophenotypic characteristics in the neoplastic cells obtained with antibodies by cell flow cytometry or immunohistochemistry. The aberrant immunophenotypes are antigen expression patterns that differ from the normal hematopoietic maturation process, which can include some different lineage antigens such as myeloid antigens in ALL or asynchronous expression of antigens. These aberrant immunophenotypes have been studied as prognostic factors and residual disease markers. In this review, some aspects of aberrant immunophenotypes are addressed, including definition, epidemiology, and potential uses.
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Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez
2020
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oai:scielo:S1665-114620200006002872020-11-26Aberrant immunophenotypes in acute lymphoblastic leukemiaCuéllar-Mendoza,Miguel E.Chávez-Sánchez,Francisco R.Dorantes-Acosta,ElisaArsuaga-Jiménez,Blanca M.Zapata-Tarrés,Marta Immunophenotypes Leukemia Lymphoblastic Hematologic Review Abstract Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic neoplasia worldwide. To classify leukemia, we analyzed the immunophenotypic characteristics in the neoplastic cells obtained with antibodies by cell flow cytometry or immunohistochemistry. The aberrant immunophenotypes are antigen expression patterns that differ from the normal hematopoietic maturation process, which can include some different lineage antigens such as myeloid antigens in ALL or asynchronous expression of antigens. These aberrant immunophenotypes have been studied as prognostic factors and residual disease markers. In this review, some aspects of aberrant immunophenotypes are addressed, including definition, epidemiology, and potential uses.info:eu-repo/semantics/openAccessInstituto Nacional de Salud, Hospital Infantil de México Federico GómezBoletín médico del Hospital Infantil de México v.77 n.6 20202020-12-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462020000600287en10.24875/bmhim.20000171 |
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México |
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English |
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| author |
Cuéllar-Mendoza,Miguel E. Chávez-Sánchez,Francisco R. Dorantes-Acosta,Elisa Arsuaga-Jiménez,Blanca M. Zapata-Tarrés,Marta |
| spellingShingle |
Cuéllar-Mendoza,Miguel E. Chávez-Sánchez,Francisco R. Dorantes-Acosta,Elisa Arsuaga-Jiménez,Blanca M. Zapata-Tarrés,Marta Aberrant immunophenotypes in acute lymphoblastic leukemia |
| author_facet |
Cuéllar-Mendoza,Miguel E. Chávez-Sánchez,Francisco R. Dorantes-Acosta,Elisa Arsuaga-Jiménez,Blanca M. Zapata-Tarrés,Marta |
| author_sort |
Cuéllar-Mendoza,Miguel E. |
| title |
Aberrant immunophenotypes in acute lymphoblastic leukemia |
| title_short |
Aberrant immunophenotypes in acute lymphoblastic leukemia |
| title_full |
Aberrant immunophenotypes in acute lymphoblastic leukemia |
| title_fullStr |
Aberrant immunophenotypes in acute lymphoblastic leukemia |
| title_full_unstemmed |
Aberrant immunophenotypes in acute lymphoblastic leukemia |
| title_sort |
aberrant immunophenotypes in acute lymphoblastic leukemia |
| description |
Abstract Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic neoplasia worldwide. To classify leukemia, we analyzed the immunophenotypic characteristics in the neoplastic cells obtained with antibodies by cell flow cytometry or immunohistochemistry. The aberrant immunophenotypes are antigen expression patterns that differ from the normal hematopoietic maturation process, which can include some different lineage antigens such as myeloid antigens in ALL or asynchronous expression of antigens. These aberrant immunophenotypes have been studied as prognostic factors and residual disease markers. In this review, some aspects of aberrant immunophenotypes are addressed, including definition, epidemiology, and potential uses. |
| publisher |
Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez |
| publishDate |
2020 |
| url |
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462020000600287 |
| work_keys_str_mv |
AT cuellarmendozamiguele aberrantimmunophenotypesinacutelymphoblasticleukemia AT chavezsanchezfranciscor aberrantimmunophenotypesinacutelymphoblasticleukemia AT dorantesacostaelisa aberrantimmunophenotypesinacutelymphoblasticleukemia AT arsuagajimenezblancam aberrantimmunophenotypesinacutelymphoblasticleukemia AT zapatatarresmarta aberrantimmunophenotypesinacutelymphoblasticleukemia |
| _version_ |
1756227135169626112 |