Aberrant immunophenotypes in acute lymphoblastic leukemia

Abstract Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic neoplasia worldwide. To classify leukemia, we analyzed the immunophenotypic characteristics in the neoplastic cells obtained with antibodies by cell flow cytometry or immunohistochemistry. The aberrant immunophenotypes are antigen expression patterns that differ from the normal hematopoietic maturation process, which can include some different lineage antigens such as myeloid antigens in ALL or asynchronous expression of antigens. These aberrant immunophenotypes have been studied as prognostic factors and residual disease markers. In this review, some aspects of aberrant immunophenotypes are addressed, including definition, epidemiology, and potential uses.

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Bibliographic Details
Main Authors: Cuéllar-Mendoza,Miguel E., Chávez-Sánchez,Francisco R., Dorantes-Acosta,Elisa, Arsuaga-Jiménez,Blanca M., Zapata-Tarrés,Marta
Format: Digital revista
Language:English
Published: Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez 2020
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462020000600287
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