Could CD64 expression be used as a predictor of positive culture results in children with febrile neutropenia?

ABSTRACT Background: Early recognition of infectious processes in neutropenic patients is hampered by the fact that these processes may have dissimilar and non-specific clinical presentations. CD64 is a neutrophil surface marker that is not expressed in non-sensitized neutrophils. When the neutrophil is exposed to tumor necrosis factor-alpha it is activated and is measured via the CD64 index. Methods: This paper evaluated the relationship between the index value of CD64 on the first day of febrile neutropenia and a positive blood culture. The correlations with white blood count, C-reactive protein and erythrocyte sedimentation rate were also evaluated. This case-control, prospective, diagnostic study included 64 episodes of neutropenia. Case group (n = 14) comprised positive blood cultures, and the control group (n = 50), negative blood cultures. Results: The median rates of CD64 were 2.1 (a ± 3.9) in the case group and 1.76 (a ± 5.02) in the control group. There was no correlation between the value of the CD64 index and blood cultures. The CD64 index was also not correlated with C-reactive protein positivity. Further- more, the CD64 index was not able to predict blood culture positivity. The sensitivity was 64.3%, the specificity was 42%, the positive predictive value was 23.7% and the negative predictive value was 80%. For C-reactive protein, the sensitivity, specificity, positive predictive value, and negative predictive value were 71.4%, 32%, 22.7%, and 80%, respectively. Conclusion: The CD64 index is not suitable for predicting the positivity of blood cultures in this specific population of patients with febrile neutropenia.

Bibliographic Details

Main Authors:	Barbosa,Gustavo Göhringer de Almeida, Farias,Mariela Granero, Ludwig,Helena Cocolichio, Stensmann,Isabel, Fernandes,Matheus Vanzin, Michalowski,Mariana Bohns, Daudt,Liane Esteves
Format:	Digital revista
Language:	English
Published:	Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000600395
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