Extreme phenotypes approach to investigate host genetics and COVID-19 outcomes

Abstract COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential candidate genes and pathways. Finally, we propose a strategy of subject’s ascertainment based on phenotypic extremes to take part in genomic studies and elucidate intrinsic risk factors involved in COVID-19 severe outcomes.

Bibliographic Details

Main Authors:	Naslavsky,Michel Satya, Vidigal,Mateus, Matos,Larissa do Rêgo Barros, Cória,Vivian Romanholi, Batista Junior,Pedro Benedito, Razuk,Álvaro, Saldiva,Paulo Hilário Nascimento, Dolhnikoff,Marisa, Schidlowski,Laire, Prando,Carolina, Cunha-Neto,Edécio, Condino-Neto,Antonio, Passos-Bueno,Maria Rita, Zatz,Mayana
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Genética 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200307
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