Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses

The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.

Bibliographic Details

Main Authors:	Silva,Aline Correa da, Brass,Karin Erica, Loreto,Elgion da Silva, Vinocur,Myriam Elizabeth, Pozzobon,Ricardo, Azevedo,Marcos da Silva
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Genética 2011
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300015
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