Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease

We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.

Bibliographic Details

Main Authors:	Zhong,Chen, Quanzhong,Yin, Genshan,Ma, Hua,Zhang, Ruolong,Zheng, Jiahong,Wang, Chunheng,Gao
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Genética 2009
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
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