A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
Plasminogen activator inhibitor-1 (PAI-1) is an important inhibitor of fibrinolysis, and increased levels of PAI-1 are associated with atheroma and myocardial infarction. A common 4G/5G insertion/deletion polymorphism located in the promoter region of PAI-1 gene has been described associated with PAI-1 activity in plasma levels. Genotyping of this polymorphism is commonly conducted with an allele-specific oligonucleotide melting technique. In the present study, we describe a quick, easy method for genotyping 4G/5G polymorphism in the promoter region of the PAI-1 gene.
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| Auteurs principaux: | , , |
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| Format: | Digital revista |
| Langue: | English |
| Publié: |
Sociedade Brasileira de Genética
1998
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| Accès en ligne: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300004 |
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