Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD4+ cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD4/µL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.

Bibliographic Details

Main Authors:	Levi,José E., Fink,Maria C.S., Canto,Cynthia L.M., Carretiero,Nadily, Matsubara,Regina, Linhares,Iara, Dores,Gérson B. das, Castelo,Adauto, Segurado,Aluísio, Uip,David E., Eluf Neto,José
Format:	Digital revista
Language:	English
Published:	Brazilian Society of Infectious Diseases 2002
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300005
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