Use of 13C-glucose breath test to assess treatment adherence in nutritional intervention trials
Abstract Objective: To validate the use of the 13C-glucose breath test to assess nutritional treatment adherence. Methods: A pilot study was conducted on eleven adults. A snack made of soybean/corn-starch was enriched with U-13C-glucose. The participants were divided in three groups that consumed the snack in different periods for two weeks (A=14 days, B=10 days and C=6 days). Breath samples were collected daily to analyse the δ 13C values with isotope-ratio mass spectrometry. Results: AUC (area under the curve) median of δ 13C values of group A was higher than group C (p = 0.029); differences were found when combining groups, A and B medians, comparing them with group C (p = 0.038). A negative association was found between AUC δ13C values and treatment intensity (Spearman rho = -0.708; p = 0.015). A cut-off ≤ 3.78 identifies subjects with less than 70% accomplishment of the treatment with 100% specificity and 86% sensitivity. Conclusions: The 13C-glucose breath test suggests a good diagnostic performance to assess treatment adherence.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza
2021
|
| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-888X2021000100113 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|