Serum oxidative stress is increased in patients with post cholecystectomy bile duct injury
Background: post-cholecystectomy bile duct injuries are identified by the onset of jaundice as well as elevated bilirubin and alkaline phosphatase levels during the peri-operative period. It is unknown how serum oxidative stress markers are modified in patients with post-cholecystectomy bile duct injuries. Objective: to determine serum oxidative stress marker levels (lipid peroxidation by-products, nitrites/nitrates and total antioxidant capacity) in patients with post-cholecystectomy bile duct injuries. Patients and methods: a prospective, transversal and analytical study was designed with two groups. Group 1: 5 healthy volunteer subjects. Group 2: 52 patients with post-cholecystectomy bile duct injuries (43 female and 9 male). An elective bilio-digestive reconstruction was performed at week 8. The serum oxidative stress marker levels were quantified by colorimetric method. Results: patients with bile duct injuries had a significant increased serum lipid peroxides (malondialdehyde and 4-hydroxy-alkenals) and nitric oxide metabolites (nitrites/nitrates) levels compared to the control group. In contrast, total antioxidant capacity in patients with bile duct injuries remained similar compared to healthy controls. Conclusions: the results show that oxidative stress is usually associated to bile duct injury.
Main Authors: | Miranda-Díaz,A. G., Hermosillo-Sandoval,J. M., Ortiz,G. G., Lizardi-García,D., Cardona-Muñoz,E. G., Pacheco-Moisés,F. |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedad Española de Patología Digestiva
2010
|
Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082010000600002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
LIVER TRANSPLANTATION FOR BILE DUCT INJURY AFTER CHOLECYSTECTOMY
by: SILVA FILHO,José Francisco Rêgo e, et al.
Published: (2019) -
The tangible consequences and intangible implications of laparoscopic cholecystectomy-associated bile duct injuries
by: Lindemann,J, et al.
Published: (2020) -
Making bile duct injuries after laparoscopic cholecystectomy a 'near-never' event
by: Lindemann,J, et al.
Published: (2020) -
ROUND LIGAMENT REPAIR OF THE BILE DUCT AS TREATMENT OF BILE DUCT INJURIES: CASE REPORT
by: IRIGOYEN,Juan Alvarado, et al.
Published: (2019) -
The relationship between bile reflux and common bile duct diameter after cholecystectomy: a clinical case-control study
by: Sami-Bostan,Mustafa, et al.
Published: (2023)