Serum oxidative stress is increased in patients with post cholecystectomy bile duct injury

Background: post-cholecystectomy bile duct injuries are identified by the onset of jaundice as well as elevated bilirubin and alkaline phosphatase levels during the peri-operative period. It is unknown how serum oxidative stress markers are modified in patients with post-cholecystectomy bile duct injuries. Objective: to determine serum oxidative stress marker levels (lipid peroxidation by-products, nitrites/nitrates and total antioxidant capacity) in patients with post-cholecystectomy bile duct injuries. Patients and methods: a prospective, transversal and analytical study was designed with two groups. Group 1: 5 healthy volunteer subjects. Group 2: 52 patients with post-cholecystectomy bile duct injuries (43 female and 9 male). An elective bilio-digestive reconstruction was performed at week 8. The serum oxidative stress marker levels were quantified by colorimetric method. Results: patients with bile duct injuries had a significant increased serum lipid peroxides (malondialdehyde and 4-hydroxy-alkenals) and nitric oxide metabolites (nitrites/nitrates) levels compared to the control group. In contrast, total antioxidant capacity in patients with bile duct injuries remained similar compared to healthy controls. Conclusions: the results show that oxidative stress is usually associated to bile duct injury.

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Autores principales:	Miranda-Díaz,A. G., Hermosillo-Sandoval,J. M., Ortiz,G. G., Lizardi-García,D., Cardona-Muñoz,E. G., Pacheco-Moisés,F.
Formato:	Digital revista
Idioma:	English
Publicado:	Sociedad Española de Patología Digestiva 2010
Acceso en línea:	http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082010000600002
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