Pyoderma gangrenosum associated with ulcerative colitis: response to infliximab

Pyoderma gangrenosum is an extraintestinal manifestation of inflammatory bowel disease that can be therapeutically troublesome. We comment on the case of a patient with clinically inactive ulcerat-ive colitis who progressively developed necrotic lesions on both tibial aspects of his legs, which corresponded both clinically and histologically to pyoderma gangrenosum. Treatment with steroids and azathioprine could not control this complication. A single dose of infliximab 5 mg/kg was given, achieving an impressive response of the skin lesions followed by complete healing 3 months later. Infliximab can be useful in the management of refractory extraintestinal manifestations of inflammatory bowel disease.

Bibliographic Details

Main Authors:	López San Román,A., Bermejo,F., Aldanondo,I., Carrera,E., Boixeda,D., Muñoz Zato,E.
Format:	Digital revista
Language:	English
Published:	Sociedad Española de Patología Digestiva 2004
Online Access:	http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082004000600008
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