Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (Bubalus bubalis)
Pharmacokinetics and urinary excretion of an intravenous dose of 5 mg.kg-1 ofloxacin were investigated in water buffalo calves. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography. Ofloxacin was rapidly distributed from the central to the peripheral compartment as evidenced by a short distribution half-life (0.09 h ± 0.003 h) and high K12 (4.7 h-1 ± 0.1 h-1), and was detected in plasma for 8 h. The large volume of distribution (2.48 L.kg-1 ± 0.18 L.kg-1) obtained in this study indicated high distribution of ofloxacin in water buffalo calves. The elimination half-life, the area under the plasma drug concentration-time curve and total body clearance were 2.11 h ± 0.13 h, 6.20 mg.mL-1 ± 0.23 mg.mL-1.h and 0.81 mL.kg-1.h-1 ± 0.03 mL.kg-1.h-1, respectively. About 18.7% of administered drug was bound to plasma proteins and approximately 32.5% of the administered dose was recovered in urine within 48 h. The results of the study indicated a favourable pharmacokinetic profile of ofloxacin in water buffalo calves, which suggests that ofloxacin may be effective against urinary pathogens in this species.
| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
South African Veterinary Association
2013
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| Online Access: | http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282013000100005 |
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