Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis

ABSTRACT: The influence of cytokine on the progression of chronic periodontitis in human immunodeficiency virus (HIV) patients is still controversial and poorly investigated. This study aimed to analyze and compare IL-6 and IFN-α levels in the gingival crevicular fluid of HIV-1-positive and HIV-1-negative patients with chronic periodontitis and different grades of tissue destruction and inflammation. Samples from the gingival crevicular sulcus were obtained from 35 HIV-1-positive individuals with chronic periodontitis and 35 seronegative patients with chronic periodontitis. Probing depth and clinical attachment level, as well as the results of the Enzyme-Linked Immunosorbent Assay for confirmation of patient diagnostics, were evaluated. Statistical analyses were performed using Student t, Mann-Whitney and Spearman tests. IL-6 levels were significantly lower, while IFN-α levels were significantly higher in HIV-1 patients. Clinical attachment level was directly associated with IFN-α levels in HIV-1 carriers, connected to probing depth in these patients. Clinical data in association with gingival crevicular fluid cytokine levels may reveal a localized immunological response pattern, which may contribute to the understanding of periodontitis pathogenesis in HIV-1 carriers.

Bibliographic Details

Main Authors:	Menezes,Sílvio Augusto Fernandes de, Araújo,Vera Cavalcente de, Napimoga,Marcelo Henrique, Menezes,Tatiany Oliveira de Alencar, Nogueira,Brenna Magdalena Lima, Fonseca,Ricardo Roberto de Souza, Martinez,Elizabeth Fernandes
Format:	Digital revista
Language:	English
Published:	Universidad de La Frontera. Facultad de Medicina 2018
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000300219
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