SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES

SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES

Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive activity.

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Bibliographic Details
Main Authors: MISHRA,RAVINESH, SIDDIQUI,ANEES A, HUSAIN,ASIF, RASHID,MOHD, PRAKASH,ATISH, TAILANG,MUKUL, KUMAR,MUNEESH, SRIVASTAVA,NEETI
Format: Digital revista
Language:English
Published: Sociedad Chilena de Química 2011
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400006
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400006

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