High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats

SUMMARY: Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-&#945;) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.

Bibliographic Details

Main Authors:	El-Bidawy,Mahmoud H, Bastawy,Nermeen, Mansour-Khalifa,Mohamed, Abdulla,Hanan, Elsayed,Rania, Rashed,Laila, Niazy,Marwa, Al-Ghamdi,Sameer, Haidara,Mohamed A
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Anatomía 2020
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100129
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