Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy

Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy

Abstract We report the case of a 38-year-old man, who developed cutaneous metastases in the left inguinal groove 15 years after curative gastrectomy for advanced gastric adenocarcinoma. Histopathologic examination revealed poorly differentiated adenocarcinoma cells. They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1. The patient underwent local excision, after the presence of other metastases was excluded. Nevertheless, local recurrence developed at the surgical bed one year later and PET/CT revealed metastases to lymph nodes, bone and skin. He died 2 years after the appearance of cutaneous metastases. We have reviewed the literature and described the immunohistochemical characteristics of cutaneous metastases from gastric adenocarcinoma.

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Main Authors: Liu,Fang, Yan,Wen Liang, Liu,Haibo, Zhang,Min, Sang,Hong
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Dermatologia 2015
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700046
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spelling oai:scielo:S0365-059620150007000462015-11-19Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomyLiu,FangYan,Wen LiangLiu,HaiboZhang,MinSang,Hong Neoplasm metastasis Skin neoplasms Stomach neoplasms Abstract We report the case of a 38-year-old man, who developed cutaneous metastases in the left inguinal groove 15 years after curative gastrectomy for advanced gastric adenocarcinoma. Histopathologic examination revealed poorly differentiated adenocarcinoma cells. They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1. The patient underwent local excision, after the presence of other metastases was excluded. Nevertheless, local recurrence developed at the surgical bed one year later and PET/CT revealed metastases to lymph nodes, bone and skin. He died 2 years after the appearance of cutaneous metastases. We have reviewed the literature and described the immunohistochemical characteristics of cutaneous metastases from gastric adenocarcinoma.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.90 n.3 suppl.1 20152015-06-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700046en10.1590/abd1806-4841.20153829
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Liu,Fang
Yan,Wen Liang
Liu,Haibo
Zhang,Min
Sang,Hong
spellingShingle Liu,Fang
Yan,Wen Liang
Liu,Haibo
Zhang,Min
Sang,Hong
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
author_facet Liu,Fang
Yan,Wen Liang
Liu,Haibo
Zhang,Min
Sang,Hong
author_sort Liu,Fang
title Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
title_short Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
title_full Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
title_fullStr Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
title_full_unstemmed Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
title_sort cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy
description Abstract We report the case of a 38-year-old man, who developed cutaneous metastases in the left inguinal groove 15 years after curative gastrectomy for advanced gastric adenocarcinoma. Histopathologic examination revealed poorly differentiated adenocarcinoma cells. They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1. The patient underwent local excision, after the presence of other metastases was excluded. Nevertheless, local recurrence developed at the surgical bed one year later and PET/CT revealed metastases to lymph nodes, bone and skin. He died 2 years after the appearance of cutaneous metastases. We have reviewed the literature and described the immunohistochemical characteristics of cutaneous metastases from gastric adenocarcinoma.
publisher Sociedade Brasileira de Dermatologia
publishDate 2015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700046
work_keys_str_mv AT liufang cutaneousmetastasesfromgastricadenocarcinoma15yearsaftercurativegastrectomy
AT yanwenliang cutaneousmetastasesfromgastricadenocarcinoma15yearsaftercurativegastrectomy
AT liuhaibo cutaneousmetastasesfromgastricadenocarcinoma15yearsaftercurativegastrectomy
AT zhangmin cutaneousmetastasesfromgastricadenocarcinoma15yearsaftercurativegastrectomy
AT sanghong cutaneousmetastasesfromgastricadenocarcinoma15yearsaftercurativegastrectomy
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