Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients

Background: We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD). Methods: 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis. Results: The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m²/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality. Conclusion: These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients.

Bibliographic Details

Main Authors:	Díez,J. J., Bossola,M., Fernández-Reyes,M. J., Stasio,E. Di, Tazza,L., Luciani,G., Codoceo,R., Iglesias,P., Rodríguez,A., González,E., Selgas,R.
Format:	Digital revista
Language:	English
Published:	Sociedad Española de Nefrología 2011
Online Access:	http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952011000200014
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