Synthesis of Novel Cinnamides and a Bis Cinnamate Bearing 1,2,3-Triazole Functionalities with Antiproliferative and Antimetastatic Activities on Melanoma Cells

The present investigation describes the synthesis of novel cinnamides and a bis cinnamate bearing 1,2,3-triazole functionalities and investigation of their antiproliferative and antimetastatic effects on melanoma cells. The necessity for the development of new chemotherapeutic agents for melanoma treatment motivated this work. Sixteen derivatives were obtained with yields ranging from 23-81% and fully characterized by spectroscopic (1H and 13C nuclear magnetic resonance, infrared) and spectrometric high resolution mass spectrometry (HRMS) techniques. The derivatives were in vitro evaluated against B16-F10 murine melanoma cell line. The most effective compound (a bis cinnamate) (6b) reduced the melanoma cell viability, generated cell cycle arrest, and influenced the metastatic behavior of melanoma cells by decreasing migration, invasion, and colony formation. Based on these findings, it is believed that compound 6b may represent an interesting scaffold to be explored toward the development of new antimelanoma agents.

Bibliographic Details

Main Authors:	Santos,Fabíola S, Vale,Juliana A. do, Santos,Lucas S, Gontijo,Talita B, Lima,Graziela D. A, Oliveira,Leandro L. de, Machado-Neves,Mariana, Teixeira,Róbson R, Freitas,Rossimiriam P. de
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021001202174
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