"Sweet Chemistry": a Green Way for Obtaining Selenium Nanoparticles Active against Cancer Cells

We present an environment friendly synthesis of selenium nanoparticles and the study of their cytotoxic activity against uterine sarcoma cancer and fibroblasts cells. Amorphous selenium (a-SeNPs) and trigonal selenium (t-SeNPs) were synthesized using D-fructose as the reducing agent and characterized by high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction analysis (XRD), inductively coupled plasma optical emission spectrometry (ICP OES), dynamic light scattering (DLS) to obtain zeta potential values and cyclic voltammetry (CV). Particularly, a-SeNPs presented high toxicity toward the resistant cancer cell line MES-SA/Dx5 and its parental MES-SA line. However, they are not toxic against P4 fibroblast cells in comparative studies.

Bibliographic Details

Main Authors:	Vieira,Adriana P., Stein,Erika M., Andreguetti,Daniel X., Cebrián-Torrejón,Gerardo, Doménech-Carbó,Antonio, Colepicolo,Pio, Ferreira,Ana Maria D. C.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2017
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001002021
Tags:	Add Tag No Tags, Be the first to tag this record!