Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N,N-diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.

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Bibliographic Details
Main Authors: Gomes,Sara L. S., Militão,Gardenia C. G., Costa,Arinice M., Pessoa,Cláudia Ó., Costa-Lotufo,Letícia V., Cunha-Junior,Edézio F., Torres-Santos,Eduardo C., Costa,Paulo R. R., Silva,Alcides J. M. da
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801573
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