New Epimeric Spirostanol and Furostanol-Type Steroidal Saponins from Cestrum laevigatum L.

Four new epimeric spirostanol and furostanol-type steroidal saponins, (25R,S)-5α-spirostan-2α,3β-diol 3-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-galactopyranoside, (25R,S)-5α-spirostan-2α,3β-diol 3-O-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→4)-β-D-galactopyranoside, 26-O-β-D-glucopyranosyl-(25R,S)-5α-furost-20-ene,2α,3β-diol 3-O-β-D-galactopyranoside and 26-O-β-D-glucopyranosyl-(25R,S)-5α-furost-20-ene,2α,3β-diol 3-O-β-D-galactopyranosyl-(1→4)-β-D-galactopyranoside, in addition to the known (25R,S)-5α-spirostan-2α,3β-diol 3-O-β-D-galactopyranoside, were isolated from Cestrum laevigatum. Compounds were submitted to cytotoxic activity assays using colorectal adenocarcinoma (HCT-116), human promyelocytic leukemia (HL-60), ovarian carcinoma (OVCAR-8), glioma (SF-295) human cancer cell lines, and the antimicrobial activity was evaluated against Candida parapsilosis, C. albicans, C. krusei, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis.

Bibliographic Details

Main Authors:	Ribeiro,Paulo R. V., Braz-Filho,Raimundo, Araújo,Ana J., Costa-Lotufo,Letícia V., Souza,Luciana G. S., Nobre Junior,Hélio V., Silva,Cecília R. da, Andrade Neto,João B. de, Silveira,Edilberto R., Lima,Mary Anne S.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001202170
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