Synthesis of Novel 2-Aryl-3-(2-morpholinoethyl)-1,3-thiazinan-4-ones Via Ultrasound Irradiation

This study describes the synthesis of fourteen thiazinanones from a multicomponent reaction of 2-morpholinoehtylamine (as primary amine), arenealdehydes (as carbonyl compound) and the mercaptopropionic acid using both conventional (thermal heating) and ultrasound methodologies. Through thermal heating methodology, the thiazinanones were obtained in 49 to 97% yields for 16 hours and through sonochemistry methodology, the reaction time was reduced for 25 minutes with yields 41 to 88%. The full identification and characterization of unpublished heterocycles were achieved by proton (1H) and carbon 13 (13C) nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and infrared. Some of them were also characterized by elemental analysis.

Bibliographic Details

Main Authors:	Gouvêa,Daniela P., Berwaldt,Gabriele A., Neuenfeldt,Patrícia D., Nunes,Ricardo J., Almeida,Wanda P., Cunico,Wilson
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000601109
Tags:	Add Tag No Tags, Be the first to tag this record!