Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia

Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia

The isolation and structure determination of new cyclic peptide alkaloid ixorine, along with five known constituents frangulanine, syringaresinol, cinnamtannin B-1, daucosterol and mannitol from the branches of Ixora brevifolia are described. The cyclic peptide frangulanine is being described for the first time in the Rubiaceae family. The structures were elucidated on their spectral data basis, mainly one- (1H, 13C, DEPT) and two-dimensional (COSY, NOESY, HSQC and HMBC) nuclear magnetic resonance (NMR) and by comparison with data from the literature. The mixture of two cyclopeptide alkaloids showed weak activity against Leishmania amazonensis.

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Bibliographic Details
Main Authors: Medina,Rebeca P., Schuquel,Ivânia T. A., Pomini,Armando M., Silva,Cleuza C., Oliveira,Cecília M. A., Kato,Lucília, Nakamura,Celso V., Santin,Silvana M. O.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000400753
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