A fast fluorimetric flow injection method to determine ibuprofen
The native fluorescence of ibuprofen was enhanced when a host-guest complex of the analyte with beta cyclodextrin (beta-CD) was formed. So, based on this fact, a flow injection method to determine ibuprofen in different pharmaceutical preparations with fluorescence detection (lambdaem 287 nm, lambdaexc 223 nm) was developed. The calibration curve was linear over the range 6.00 - 60.0 mg L-1 of ibuprofen and the detection limit (LOD) for S/N=3 was 4.5 mg L-1. The relative standard deviation was 1.2% and the sample throughput 240 h-1. The method was validated by comparing the proposed and the official method to commercial preparation samples.
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| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2006
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000700033 |
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