Biological Activity of Quinoline Alkaloids from Raulinoa echinata and X-ray Structure of Flindersiamine

Phytochemical survey of stems and leaves extracts of the South Brazilian endemic plant Raulinoa echinata Cowan, Rutaceae, led to the isolation of known furoquinoline alkaloids: the widespread skimmianine; kokusaginine, maculine, flindersiamine, and also quinolone derivatives: 1-methyl-2-n-nonyl-4-quinolone, 2-n-nonyl-4-quinolone and 1-methyl-2-phenyl-4-quinolone. These alkaloids showed antifungal activity against Leucoagaricus gongylophorus; the symbiotic fungus of leaf-cutting ants (Atta sexdens). They were inactive or displayed weak inhibitory activity when assayed in vitro against trypomastigote forms of Trypanosoma cruzi. In this paper, the isolation, structure elucidation and bioactivity results of these compounds are reported together with the X-ray structure of flindersiamine.

Détails bibliographiques

Auteurs principaux:	Biavatti,Maique W., Vieira,Paulo C., Silva,M. Fátima das G. F. da, Fernandes,João B., Victor,Sandra R., Pagnocca,Fernando C., Albuquerque,Sérgio, Caracelli,Ignez, Zukerman-Schpector,Julio
Format:	Digital revista
Langue:	English
Publié:	Sociedade Brasileira de Química 2002
Accès en ligne:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000100010
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