Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats

ABSTRACT Purpose: The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats. Methods: Forty-seven female Wistar rats were submitted to pelvic radiation and divided into eight groups: control A, mesalazine A, chondroitin A, and conjugate A, gavage of the according substance two weeks after irradiation and sacrifice three weeks after oral treatment; control C, mesalazine C, chondroitin C, and conjugate C, sacrifice six weeks after oral treatment. The rectum was submitted to histological characterization for each of the findings: inflammatory infiltrate, epithelial degeneration, mucosal necrosis, and fibrosis. Results: The inflammatory infiltrate was more intense in chondroitin A, mesalazine A, and conjugate C. The collagen deposition was less intense in chondroitin A, and mesalazine A, and more intense in control C. Conclusions: Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.

Bibliographic Details

Main Authors:	Nunes,Vinícius Rodrigues Taranto, Vidigal,Paula Vieira Teixeira, Pereira,Márcio Tadeu, Ladeira,Luís Carlos Duarte, Caliari,Marcelo Vidigal, Oliveira,Fabrício Marcus Silva, Cesar,Aina Liz Alves, Faraco,André Augusto Gomes, Barbuto,Rafael Calvão, Duval-Araujo,Ivana
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000800205
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