Chemical constituents from Bauhinia acuruana and their cytotoxicity

Chemical constituents from Bauhinia acuruana and their cytotoxicity

ABSTRACT Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2'-hydroxy-2,3,5-trimethoxybibenzyl (1), (2R,3S)-2-(3,4'-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol (2), together with fourteen known ones (3–16). The structures of the compounds were established by spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR data, followed by comparison with previously reported data from the literature. Compounds 1, 2, 6, 7, 8 and 9 were evaluated for their cytotoxicity, which turned out to be marginal in a panel of six human cancer cell lines.

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Bibliographic Details
Main Authors: Góis,Roberto W.S., Sousa,Leôncio M. de, Silva,Horlando C. da, Silva,Francisco E.F. da, Pimenta,Antonia T.A., Lima,Mary A.S., Arriaga,Angela M.C., Lemos,Telma L.G., Braz-Filho,Raimundo, Militão,Gardenia C.G., Silva,Paulo B.N. da, Gonçalves,Francisco J.T., Santiago,Gilvandete M.P.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Farmacognosia 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000600711
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