Evaluation of the use of tranexamic acid in total knee arthroplasty

ABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.

Bibliographic Details

Main Authors:	Almeida,Mariana Diana Chaves de, Albuquerque,Rodrigo Pires e, Palhares,Guilherme Mathias, Almeida,Juliana Patrícia Chaves de, Barretto,João Mauricio, Cavanellas,Naasson
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Ortopedia e Traumatologia 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761
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