Decreased expression of cardiac troponin C is associated with cardiac lesions in Amorimia exotropica poisoned cattle

The plants which cause sudden death of cattle in Brazil occupy a leading position for losses in the cattle industry. Amorimia exotropica is one of the plants pertaining to this group. Diagnostic findings in these cases may be inconclusive; further knowledge is necessary. This paper identifies cardiac lesions through anti-cardiac troponin C (cTnC) immunehistochemistry performed in tissues from cattle poisoned after consumption of A.exotropica in southern Brazil. Heart fragments from nine A. exotropica-poisoned cattle were studied immunohistochemically using anti-human cTnC as the primary antibody. In the hearts from all of the poisoned cattle, there was a sharp decrease in the cTnC expression level in the cytoplasm of groups of cardiomyocytes. A significant decrease in anti-cTnC immunoreactivity occurred particularly in degenerated or necrotic cardiomyocytes. Occasional groups of cells showed complete loss of immunolabeling. In the remaining intact cardiomyocytes from poisoned cattle and in cardiomyocytes from six cattle that died from other causes there was intense cytoplasmic staining.

Bibliographic Details

Main Authors:	Pavarini,Saulo Petinatti, Bandinelli,Marcele Bettim, Juffo,Gregory Duarte, Souza,Suyene Oltramari de, Driemeier,David, Cruz,Cláudio Estêvão Farias da
Format:	Digital revista
Language:	English
Published:	Colégio Brasileiro de Patologia Animal - CBPA 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2012001000010
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