Spectrophotometric flow injection system for determination of Zn2+ in ophthalmic formulations using Alizarin red S
A spectrophotometric flow injection method for the determination of Zn(II) in ophthalmic formulations was developed. In this work, Zn(II) ion was complexed with Alizarin red S in borate buffer solution (pH 9.0) and the chromophore produced was monitored at 520 nm. The analytical curve was linear in the Zn(II) concentration range from 6.05 x 10-6 to 1.50 x 10-4 mol L-1 with a detection limit of 3.60 x 10-6 mol L-1. Recoveries ranged from 96.3 to 105 % and a relative standard deviation of 1.2 % (n = 10) for 5.5x10-5 mol L-1 Zn(II) reference solution were obtained. The sampling rate was 60 h-1 and the results obtained of Zn(II) in ophthalmic products using this procedure are in close agreement with those obtained using a comparative spectrophotometric procedure at 95 % confidence level.
| Autores principales: | , |
|---|---|
| Formato: | Digital revista |
| Idioma: | English |
| Publicado: |
Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
2009
|
| Acceso en línea: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702009000200008 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|