ESTUDO TEÓRICO E EXPERIMENTAL DE ESTRUTURA E REATIVIDADE RELACIONADO AO METABOLISMO E TOXICIDADE DO PARACETAMOL

An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, and chemical reactivity using frontier orbitals and Fukui index were used explaining the main products between N-acetyl-p-benzosemiquinone (NAPQI) and thiolic compounds. The chemoprotection mechanisms by N-acetyl-cysteine on high dosage of paracetamol are consistent with theoretical and experimental results. The methods also described the relationship between the chemical reactivity of quinone-imine system and the induced-toxicity of paracetamol by Michael reaction. These results can be applied in experimental pharmaceutical chemistry teaching.

Bibliographic Details

Main Authors:	Borges,Rosivaldo S., Costa,Wanda S., Gurrão,Ellen P. C., Holanda,Luiz H. C., Sousa,Alanna C. L. F., Vale,Joyce K. L., Alves,Cláudio N., Silva,Albérico B. F. da
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2022
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901160
Tags:	Add Tag No Tags, Be the first to tag this record!