SÍNTESE, CARACTERIZAÇÃO E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA DE COMPOSTOS CICLOPALADADOS CONTENDO COMO LIGANTES BENZALDEIDOXIMA ORTOMETALADA E ETILENOTIOURÉIA

The halide-bridge cleavage reaction of the [Pd(C2 ,N-bzox)(µ-Cl)]2 compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C2 ,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd(C2 ,N-bzox)(X)(L)] {X = Br- (2), I- (3)}. All compounds were characterized by melting point, elemental analyses, infrared and 1H- and 13C{1H}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. The cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin.

Bibliographic Details

Main Authors:	Thomazella,Nathália A., Lemos,Sahra C., Souza,Ronan F. F. de, Souza,Rodrigo A. de, Mauro,Antonio E., Carlos,Iracilda Z., Netto,Adelino V. G.
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018001001150
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