Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity
Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) ranging from 1 to 8. Compounds 4, 5, and 7 showed the best protection against UVB sunrays, while compounds 5, 6, and 7 presented the best results for protection from UVA, so compound 7 had the most balanced protection overall. Results for compounds 4, 8, and 9 are reported for the first time in the literature.
Main Authors: | , , , , , , , , , |
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Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Química
2014
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000600014 |
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