Constituintes químicos das cascas do caule de Vochysia thyrsoidea Pohl. (Vochysiaceae) e avaliação das atividades citotóxica e inibitória frente as catepsinas B e K

A new flavonoid, catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside, along with known compounds, catechin-3-O-α-rhamnopyranoside, 3-oxo-urs-12-en-28-oic acid, 2,4,6-trimethoxybenzoic acid, 2-butyl-D-fructofuranoside and 1-butyl-D-fructofuranoside, has been isolated from the stem bark of V. thyrsoidea. These compounds were assayed for inhibition of protease activity (cathepsins B and K) and against cancer cell lines. Catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside showed moderate inhibitory activity (IC50 = 62.02 µM) against cathepsin B while 2-butyl-D-fructofuranoside was the most potent against a strain of CNS (SF-295) and human leukemia (HL-60) with IC50 = 36.80 µM and IC50 = 25.37 µM, respectively.

Bibliographic Details

Main Authors:	Sousa,Lorena Ramos Freitas de, Silva,Jame's A. da, Vieira,Paulo Cezar, Costa,Maísa Borges, Santos,Mirley Luciene dos, Sbardelotto,Aline Borba, Pessoa,Cláudia do Ó, Moraes,Manoel Odorico de, Menezes,Antônio Carlos Severo
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2014
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200016
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