Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, ¹H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.

Detalles Bibliográficos

Autores principales:	Rodrigues,Vanessa G., Duarte,Lucienir P., Silva,Grácia D. F., Silva,Fernando C., Góes,Jefferson V., Takahashi,Jacqueline A., Pimenta,Lúcia P. S., Vieira Filho,Sidney A.
Formato:	Digital revista
Idioma:	English
Publicado:	Sociedade Brasileira de Química 2012
Acceso en línea:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700017
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