Determinação condutométrica de cloridrato de metformina em formulações farmacêuticas empregando nitrato de prata como titulante
A simple, precise, rapid and low-cost conductometric titration method for the determination of metformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrant is proposed. The method was based on the chemical reaction between the chloride of metformin hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The method was applied for MET determination in three pharmaceuticals and the obtained results with proposed method were in close agreement with those results obtained using an official method of the British Pharmacopoeia, at a 95% confidence level.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Digital revista |
| Language: | Portuguese |
| Published: |
Sociedade Brasileira de Química
2009
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000700043 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|