Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler: isolamento, modificações estruturais e avaliação das atividades antibiótica e citotóxica

From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were obtained norlichexanthone, 3-O-methylnorlichexanthone, 3-O-methyl-6-O-prenylnorlichexanthone, 3,6-di-O-prenyl-norlichexanthone, 3,6-bis[(3,3-dimethyloxyran-2-il)methoxy]-1-hydroxy-8-methyl-9H-xanten-9-one and 3,6-bis[3-(dimethylamine)propoxy]-1-hydroxy-8-methyl-9H-xanten-9-one. The last compound was the most active against S. aureus.

Bibliographic Details

Main Authors:	Micheletti,Ana C., Beatriz,Adilson, Lima,Dênis Pires de, Honda,Neli K., Pessoa,Cláudia do Ó, Moraes,Manoel Odorico de, Lotufo,Letícia Veras, Magalhães,Hemerson Iury Ferreira, Carvalho,Nádia C. P.
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2009
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000100003
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