Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Digital revista |
| Language: | Portuguese |
| Published: |
Sociedade Brasileira de Química
2008
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700032 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|